CalmAid®

Clinically studied lavender oil supplement to help reduce feelings of tension and stress.*

Available in: 1 | 12 Softgels
  •  Gluten-Free
  •  No Added Sugar
  •  Softgel
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Overview

Reduces tension & stress*

Feel more relaxed with CalmAid®, the advanced lavender oil supplement studied to help you reduce feelings of tension & stress.*

  • Once daily softgel
  • Easy-to-swallow
  • Safe for daily use
  • Non-habit forming
  • Non-drowsy

CalmAid contains Silexan™, the orally administered lavender oil used in clinical studies.

Take 1 softgel daily with a glass of water, or as directed by a healthcare professional.

Product Label

Serving Size: 1 Softgel Amount/Serving %DV
Silexan Lavender (Lavandula angustifolia) Essential Oil 80 mg **

Canola Oil (non-GMO), Gelatin (softgel), Glycerin, Sorbitol, Annatto Extract Color

Frequently Asked Questions

Q:
Does Lavender Oil Have Estrogenic Effects?
A:
 
Neither traditional use1 nor controlled clinical trials of oral lavender oil2,3 have suggested estrogenic effects.
 
In one brief report, Henley and colleagues described three cases of otherwise healthy boys with prepubertal gynecomastia, all of whom had normal serum concentrations of endogenous steroids and none of whom were confirmed to have been exposed to exogenous endocrine disruptors .4 The repeated topical application of one or more over-the-counter personal care products that contained lavender oil or lavender and tea tree oils was documented for all three patients. The authors performed in vitro tests that suggested hormonal activities of the oils, which they theorized may have contributed to an imbalance in estrogen and androgen pathway signaling. We are aware of no other reports in the medical literature of gynecomastia or other “estrogenic” symptoms in which lavender oil was assumed to be a factor.
 
The responses to this case report highlight several limitations. Product names were not provided, and no information was given about constituents of the products.5 Herbal products, and particularly cosmetic products, are widely reported as having a high degree of variability, adulteration, and contamination 6,7 and many supplements fail to meet their own label claims for identity, purity, and potency of ingredients.8 Plastic containers may contain phthalates, which are known endocrine disrupters.9-11 Since these molecules with hormone-modulating activity are fat soluble, topically applied oils may facilitate absorption of environmental endocrine disrupters by concentrating them and delivering them into cells.12 This and other possible causes of gynecomastia in these boys were not examined by the authors of the report.
 
It should also be noted that none of their hormonal testing showed abnormal results, except in Patient 2, who had elevated levels of testosterone, not estrogen. There was no reporting of ultrasound examination or biopsy results.5 Most critically, the in vitro experiments conducted by Henley and colleagues used concentrations of lavender oil which could not have been obtained from the products as used by the three boys. It is therefore not valid to conclude that lavender oil or tea tree oil caused the estrogenic signs observed in these three cases.
 
In a clinical trial, topical application of lavender lotion and tea tree oil was specifically investigated for estrogenic effects in women with postmenopausal hot flashes. The products produced no estrogenic effects, and did not affect either FSH levels or hot flashes.13 More recently, topical application of lavender oil also failed to elicit estrogenic responses in laboratory animals.

Estrogenic effects have been reported for other essential oils and plants; some lavender oil constituents could possibly exert such activity at high concentrations. However, the best available evidence suggests that any estrogenic effect of lavender oil, if it exists at all, would be weak. It should go without saying that in vitro testing alone is not adequate grounds for indicting traditionally used products and raising public fear, particularly when superior evidence from clinical trials contradicts those findings.
 
Lavender oil products for oral use should comply with the most stringent quality standards, such as those set forth in the European Pharmacopoeia.14  When in compliance with or exceeding these standards, and used at the recommended dose, we see no reason to expect any estrogenic effects. The reason the product is not recommended for children is not because of any estrogenic activity, but simply because there are insufficient data available pertaining to this product’s use in children. It is purely precautionary advice. The same can be said for avoiding use in pregnancy and lactation.
 
 
REFERENCES
1.Blumenthal M, ed. Lavender flower. In: The Complete German Commission E Monographs. Austin, TX: American Botanical Council; 1998:159–60.
2.Kasper S, Gastpar M, Müller WE, et al. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol 2010;25:277–87.
3. Woelk H, Schläfke S.  A multi-center, double-blind, randomised study of the Lavender oil preparation Silexan in comparison to Lorazepam for generalized anxiety disorder. Phytomedicine 2010;17:94–9. Epub 2009 Dec 3.
4. Henley DK, Lipson N, Korach KS, Bloch CA. Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 2007;356:479–85
5. Kemper KJ, Romm AJ, Gardiner P. RE: Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 2007;356:2541–2.
6. Homer LE, Leach DN, Lea D, Slade Lee L, Henry RJ, Baverstock PR. Natural variation in the essential oil content of Melaleuca alternifolia Cheel (Myrtaceae). Biochem Syst Ecol 2000;
28:367–82.
7. Keane FM, Munn SE, du Vivier AW, Taylor NF, Higgins EM. Analysis of Chinese herbal creams prescribed for dermatological conditions. BMJ 1999;318:563–4.
8. Garrard J, Harms S, Eberly LE, Matiak A. Variations in product choices of frequently purchased herbs: caveat emptor. Arch Intern Med 2003;163:2290–5.
9. Paris F, Jeandel C, Servant N, Sultan C. Increased serum estrogenic bioactivity in three male newborns with ambiguous genitalia: a potential consequence of prenatal exposure to environmental endocrine disruptors. Environ Res 2006;100:39–43.
10. Brevini TA, Zanetto SB, Cillo F. Effects of endocrine disruptors on developmental and reproductive functions. Curr Drug Targets Immune Endocr Metabol Disord 2005;5:1–10.
11. Colon I, Caro D, Bourdony CJ, Rosario O. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ Health Perspect 2000;108:895–900.
12. Kalyon S. RE: Prepubertal gynecomastia linked to lavender and tea tree oils. N Engl J Med 2007;356:2542.
13. Cohn RD, Bornhauser C, MacManus D, Sadakane M, Read W. A study of lavender and tea tree oils on postmenopausal FSH levels and hot flash severity. J Clin Oncol 2009 May 20;27(15S):1516 [abstract].
14.  [No author listed]. Lavender oil (Lavandulae aetheroleum). European Pharmacopoeia 2010;1338:1164–5.

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Caution: Not intended for use with children. Do not use if pregnant or nursing. If taking prescription medications, consult a healthcare professional before use. In clinical studies, burping with a mild lavender aroma has been reported in a small number of users.

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