For Estrogen Metabolism*

Support the activity of enzymes that improve estrogen metabolism with the unique benefits of DIM-Plus.* Diindolylmethane, or DIM, is a phytonutrient that is found in vegetables like broccoli, kale, cauliflower, and cabbage.

The DIM-Plus Difference

DIM-Plus contains Indolplex BR-DIM® complex, an enhanced bioavailable delivery system for diindolymethane.


DIM-Plus™ Directions and/or Dosage

Women take 2 capsules daily with food. Men take 2 capsules twice daily with food. For intensive use (Women/Men): take up to double the recommended dose.


Do not use if pregnant, nursing, or attempting to become pregnant. A harmless but noticeable change in urine color may occur during usage. If taking any medications, consult a healthcare professional before use.

Keep out of reach of children.


Patient Support

There is no Patient Support information available for this product


  • A. Diindolylmethane (pronounced: dye-indo-leel-methane), or DIM for short, as well as indole-3 carbinol (I3C) are plant nutrients found in broccoli, cauliflower, cabbage, and other related vegetables. Research has shown that DIM improves the way estrogen and other reproductive hormones are metabolized in the body.* However, the research on I3C has been mixed, with some studies showing benefits and other studies having negative results. As a dietary supplement, DIM provides the exact compounds that are found in vegetables. It's fully active and ready to be absorbed, while IC3 must first be synthesized into DIM after it is digested. When combined with vitamin E and phosphatidylcholine, DIM is highly absorbable. IC3, on the other hand, has an unpredictable absorption rate. The stability of IC3 is very low compared to DIM. Some research has shown IC3 may cause certain side effects, including stomach upset and dizziness; DIM has no known side effects. Therefore, DIM-Plus™ features active DIM. There is no I3C in the product.

  • A. The BioResponse-DIM in DIM-Plus™ has been tested in both animal and clinical trials with regard to its potential effect on liver metabolism as it relates to oral contraceptive metabolism. The detailed animal and clinical testing have both shown that BioResponse-DIM does not influence the activity of the critical liver enzyme, CYP3A4, which is responsible for metabolizing ethinyl estradiol, the estrogen component in oral contraceptives. In contrast, other compounds have been found to increase the activity of this enzyme and have thus been associated with reducing the efficacy of oral contraceptives. Based on the desire of many women to use DIM in combination with oral contraceptives, BioResponse has conducted preliminary direct testing of combined use of BioResponse-DIM and oral contraceptives. Formal interaction testing with oral contraceptives has not yet been undertaken; however, preliminary human testing has indicated no evidence for interaction. In preliminary tests, normal levels of the birth control estrogen (ethinyl estradiol) were detected in the subjects' blood both prior to and while taking BioResponse-DIM 300 mg/day without significant change.  This preliminary evidence supports the effectiveness of oral contraceptives during supplemental use with BioResponse-DIM. Consistent with this evidence, women on oral birth control have been taking BioResponse-DIM without reported reduced efficacy or other adverse events.

  • A. DIM is short for Diindolylmethane.

  • A. Yes. Men can take 2 capsules daily with food.

  • A. The "plus" is 100mg of spinach, cabbage and broccoli powder.

Didn't get the answer you need?

Contact Us

Setting the Gold Standard for Quality

At Nature's Way, quality is more than a set of tests. It's about doing the right thing - every time - without compromise.

Learn More
Ask the Expert

Ask the experts

Answering your biggest wellness questions, together.

Whether you’re curious about supplements, want to learn more about an ingredient, or are ready to live a healthier lifestyle, we have experts that are here to help.

View Questions